Fatiga y actividad física en mujeres con y sin hormonoterapia tras cáncer de mama. Estudio transversal.
Resumen
Objetivos: El objetivo principal fue determinar y comparar la presencia de fatiga y el nivel de actividad física en mujeres supervivientes de cáncer de mama con y sin hormonoterapia. El objetivo secundario fue explorar las posibles correlaciones entre la fatiga, la actividad física, el dolor y la funcionalidad, la autoeficacia y la calidad de vida.
Métodos: Se realizó un estudio descriptivo transversal desde el CSEU La Salle. Se incluyeron mujeres tratadas quirúrgicamente por cáncer de mama y que hubieran finalizado radioterapia y/o quimioterapia hace más de 3 meses y menos de 5 años. Se creó y divulgó un cartel informativo con el enlace a un formulario online. Las variables principales fueron severidad de fatiga (QuickPIPER) y nivel de actividad física (IPAQ). Como secundarias, calidad de vida (FBSI), discapacidad y dolor en miembros inferiores (WOMAC) y autoeficacia frente al dolor (PSE-Q).
Resultados: 60 mujeres conformaron la muestra. Aquellas con hormonoterapia presentan más METS semanales (p=,047), pero no diferente severidad de fatiga. Las mujeres con mayor nivel de actividad física muestran menos fatiga, dolor y discapacidad, y más autoeficacia y calidad de vida. El mayor IMC parece relacionarse con más severidad de fatiga (p<,01) y menos METS semanales (p<,01).
Conclusión: Según nuestros resultados, la hormonoterapia no parece asociarse a más fatiga relacionada con cáncer. En mujeres con o sin hormonoterapia tras cáncer de mama la actividad física parece proteger de la fatiga y otras secuelas físico-funcionales, por lo que el ejercicio se plantea como indispensable en su abordaje.
Cómo citar
Referencias
Abrahams, H. J. G., Gielissen, M. F. M., Schmits, I. C., Verhagen, C. A. H. H. V. M., Rovers, M. M., & Knoop, H. (2016). Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: a meta-analysis involving 12 327 breast cancer survivors. Annals of Oncology: Official Journal of the European Society for Medical Oncology, 27(6), 965–974. https://doi.org/10.1093/annonc/mdw099 DOI: https://doi.org/10.1093/annonc/mdw099
Al Maqbali, M., Al Sinani, M., Al Naamani, Z., Al Badi, K., & Tanash, M. I. (2021). Prevalence of Fatigue in Patients With Cancer: A Systematic Review and Meta-Analysis. Journal of Pain and Symptom Management, 61(1), 167–189.e14. https://doi.org/10.1016/j.jpainsymman.2020.07.037 DOI: https://doi.org/10.1016/j.jpainsymman.2020.07.037
Álvarez-Bustos, A., de Pedro, C. G., Romero-Elías, M., Ramos, J., Osorio, P., Cantos, B., Maximiano, C., Méndez, M., Fiuza-Luces, C., Méndez-Otero, M., Martín, S., Cebolla, H., & Ruiz-Casado, A. (2021). Prevalence and correlates of cancer-related fatigue in breast cancer survivors. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 29(11), 6523–6534. https://doi.org/10.1007/s00520-021-06218-5 DOI: https://doi.org/10.1007/s00520-021-06218-5
Berger, A. M., Mooney, K., Alvarez-Perez, A., Breitbart, W. S., Carpenter, K. M., Cella, D., Cleeland, C., Dotan, E., Eisenberger, M. A., Escalante, C. P., Jacobsen, P. B., Jankowski, C., LeBlanc, T., Ligibel, J. A., Loggers, E. T., Mandrell, B., Murphy, B. A., Palesh, O., Pirl, W. F., Plaxe, S. C., … National comprehensive cancer network (2015). Cancer-Related Fatigue, Version 2.2015. Journal of the National Comprehensive Cancer Network: JNCCN, 13(8), 1012–1039. https://doi.org/10.6004/jnccn.2015.0122 DOI: https://doi.org/10.6004/jnccn.2015.0122
Bower, J. E., Bak, K., Berger, A., Breitbart, W., Escalante, C. P., Ganz, P. A., Schnipper, H. H., Lacchetti, C., Ligibel, J. A., Lyman, G. H., Ogaily, M. S., Pirl, W. F., Jacobsen, P. B., & American Society of Clinical Oncology (2014). Screening, assessment, and management of fatigue in adult survivors of cancer: an American Society of Clinical oncology clinical practice guideline adaptation. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 32(17), 1840–1850. https://doi.org/10.1200/JCO.2013.53.4495 DOI: https://doi.org/10.1200/JCO.2013.53.4495
Bower, J. E., Ganz, P. A., Desmond, K. A., Rowland, J. H., Meyerowitz, B. E., & Belin, T. R. (2000). Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 18(4), 743–753. https://doi.org/10.1200/JCO.2000.18.4.743 DOI: https://doi.org/10.1200/JCO.2000.18.4.743
Browall, M., Mijwel, S., Rundqvist, H., & Wengström, Y. (2018). Physical Activity During and After Adjuvant Treatment for Breast Cancer: An Integrative Review of Women's Experiences. Integrative Cancer Therapies, 17(1), 16–30. https://doi.org/10.1177/1534735416683807 DOI: https://doi.org/10.1177/1534735416683807
Butt, Z., Rosenbloom, S. K., Abernethy, A. P., Beaumont, J. L., Paul, D., Hampton, D., Jacobsen, P. B., Syrjala, K. L., Von Roenn, J. H., & Cella, D. (2008). Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy. Journal of the National Comprehensive Cancer Network : JNCCN, 6(5), 448–455. https://doi.org/10.6004/jnccn.2008.0036 DOI: https://doi.org/10.6004/jnccn.2008.0036
Campos, M. P. O., Hassan, B. J., Riechelmann, R., & Del Giglio, A. (2011). Cancer-related fatigue: a practical review. Annals of Oncology: Official Journal of the European Society for Medical Oncology, 22(6), 1273–1279. https://doi.org/10.1093/annonc/mdq458 DOI: https://doi.org/10.1093/annonc/mdq458
Craig, C. L., Marshall, A. L., Sjöström, M., Bauman, A. E., Booth, M. L., Ainsworth, B. E., Pratt, M., Ekelund, U., Yngve, A., Sallis, J. F., & Oja, P. (2003). International physical activity questionnaire: 12-country reliability and validity. Medicine and Science in Sports and Exercise, 35(8), 1381–1395. https://doi.org/10.1249/01.MSS.0000078924.61453.FB DOI: https://doi.org/10.1249/01.MSS.0000078924.61453.FB
Cuesta-Vargas, A. I., Férnandez-Lao, C., Cantarero-Villanueva, I., Castro-Sánchez, A. M., Fernández-de-Las Peñas, C., Polley, M. J., & Arroyo-Morales, M. (2013). Psychometric properties of the QuickPIPER: a shortened version of the PIPER Fatigue scale. European Journal of Cancer Care, 22(2), 245–252. https://doi.org/10.1111/ecc.12022 DOI: https://doi.org/10.1111/ecc.12022
Doré, I., Plante, A., Peck, S. S., Bedrossian, N., & Sabiston, C. M. (2022). Physical activity and sedentary time: associations with fatigue, pain, and depressive symptoms over 4 years post-treatment among breast cancer survivors. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 30(1), 785–792. https://doi.org/10.1007/s00520-021-06469-2 DOI: https://doi.org/10.1007/s00520-021-06469-2
Drillon, P., Desvergée, A., Prevost, V., & Blaizot, X. (2023). Impact de l’activité physique adaptée sur les douleurs articulaires induites sous hormonothérapie adjuvante du cancer du sein : une revue de la littérature [Impact of adapted physical activity on joint pain induced under adjuvant hormone therapy for breast cancer: A review of the literature]. Annales Pharmaceutiques Francaises, 81(1), 1–12. https://doi.org/10.1016/j.pharma.2022.06.003 DOI: https://doi.org/10.1016/j.pharma.2022.06.003
Emery, J., Butow, P., Lai-Kwon, J., Nekhlyudov, L., Rynderman, M., & Jefford, M. (2022). Management of common clinical problems experienced by survivors of cancer. Lancet (London, England), 399(10334), 1537–1550. https://doi.org/10.1016/S0140-6736(22)00242-2 DOI: https://doi.org/10.1016/S0140-6736(22)00242-2
Escobar, A., Quintana, J. M., Bilbao, A., Azkárate, J., & Güenaga, J. I. (2002). Validation of the Spanish version of the WOMAC questionnaire for patients with hip or knee osteoarthritis. Western Ontario and McMaster Universities Osteoarthritis Index. Clinical Rheumatology, 21(6), 466–471. https://doi.org/10.1007/s100670200117 DOI: https://doi.org/10.1007/s100670200117
Fan, H. G., Houédé-Tchen, N., Yi, Q. L., Chemerynsky, I., Downie, F. P., Sabate, K., & Tannock, I. F. (2005). Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 23(31), 8025–8032. https://doi.org/10.1200/JCO.2005.01.6550 DOI: https://doi.org/10.1200/JCO.2005.01.6550
Fleming, L., Agnew, S., Peddie, N., Crawford, M., Dixon, D., & MacPherson, I. (2022). The impact of medication side effects on adherence and persistence to hormone therapy in breast cancer survivors: A quantitative systematic review. Breast (Edinburgh, Scotland), 64, 63–84. https://doi.org/10.1016/j.breast.2022.04.010 DOI: https://doi.org/10.1016/j.breast.2022.04.010
Franzoi, M. A., Agostinetto, E., Perachino, M., Del Mastro, L., de Azambuja, E., Vaz-Luis, I., Partridge, A. H., & Lambertini, M. (2021). Evidence-based approaches for the management of side-effects of adjuvant endocrine therapy in patients with breast cancer. The Lancet. Oncology, 22(7), e303–e313. https://doi.org/10.1016/S1470-2045(20)30666-5 DOI: https://doi.org/10.1016/S1470-2045(20)30666-5
Heins, M. J., de Ligt, K. M., Verloop, J., Siesling, S., Korevaar, J. C., & PSCCR group (2022). Adverse health effects after breast cancer up to 14 years after diagnosis. Breast (Edinburgh, Scotland), 61, 22–28. https://doi.org/10.1016/j.breast.2021.12.001 DOI: https://doi.org/10.1016/j.breast.2021.12.001
Juvet, L. K., Thune, I., Elvsaas, I. K. Ø., Fors, E. A., Lundgren, S., Bertheussen, G., Leivseth, G., & Oldervoll, L. M. (2017). The effect of exercise on fatigue and physical functioning in breast cancer patients during and after treatment and at 6 months follow-up: A meta-analysis. Breast (Edinburgh, Scotland), 33, 166–177. https://doi.org/10.1016/j.breast.2017.04.003 DOI: https://doi.org/10.1016/j.breast.2017.04.003
Kang, K. D., Bae, S., Kim, H. J., Hwang, I. G., Kim, S. M., & Han, D. H. (2017). The Relationship between Physical Activity Intensity and Mental Health Status in Patients with Breast Cancer. Journal of Korean Medical Science, 32(8), 1345–1350. https://doi.org/10.3346/jkms.2017.32.8.1345 DOI: https://doi.org/10.3346/jkms.2017.32.8.1345
Khosravi, N., Stoner, L., Farajivafa, V., & Hanson, E. D. (2019). Exercise training, circulating cytokine levels and immune function in cancer survivors: A meta-analysis. Brain, behavior, and immunity, 81, 92–104. https://doi.org/10.1016/j.bbi.2019.08.187 DOI: https://doi.org/10.1016/j.bbi.2019.08.187
Kwekkeboom, K. L., Tostrud, L., Costanzo, E., Coe, C. L., Serlin, R. C., Ward, S. E., & Zhang, Y. (2018). The Role of Inflammation in the Pain, Fatigue, and Sleep Disturbance Symptom Cluster in Advanced Cancer. Journal of Pain and Symptom Management, 55(5), 1286–1295. https://doi.org/10.1016/j.jpainsymman.2018.01.008 DOI: https://doi.org/10.1016/j.jpainsymman.2018.01.008
Lovelace, D. L., McDaniel, L. R., & Golden, D. (2019). Long-Term Effects of Breast Cancer Surgery, Treatment, and Survivor Care. Journal of Midwifery & Women's Health, 64(6), 713–724. https://doi.org/10.1111/jmwh.13012 DOI: https://doi.org/10.1111/jmwh.13012
Ma, Y., He, B., Jiang, M., Yang, Y., Wang, C., Huang, C., & Han, L. (2020). Prevalence and risk factors of cancer-related fatigue: A systematic review and meta-analysis. International Journal of Nursing Studies, 111, 103707. https://doi.org/10.1016/j.ijnurstu.2020.103707 DOI: https://doi.org/10.1016/j.ijnurstu.2020.103707
Martín-Aragón M., Pastor M.A., Rodríguez-Marín J., March M.J., Lledó A., López-Roig , 1. (2017). Percepción de autoeficacia en dolor crónico. adaptación y validación de la Chronic Pain Self Efficacy Scale. Revista de Psicología de la Salud, 11(1), 51-76. https://doi.org/10.21134/pssa.v11i1.799
Matias, M., Baciarello, G., Neji, M., Di Meglio, A., Michiels, S., Partridge, A. H., Bendiane, M. K., Fizazi, K., Ducreux, M., Andre, F., & Vaz-Luis, I. (2019). Fatigue and physical activity in cancer survivors: A cross-sectional population-based study. Cancer Medicine, 8(5), 2535–2544. https://doi.org/10.1002/cam4.2060 DOI: https://doi.org/10.1002/cam4.2060
Plevritis, S. K., Munoz, D., Kurian, A. W., Stout, N. K., Alagoz, O., Near, A. M., Lee, S. J., van den Broek, J. J., Huang, X., Schechter, C. B., Sprague, B. L., Song, J., de Koning, H. J., Trentham-Dietz, A., van Ravesteyn, N. T., Gangnon, R., Chandler, Y., Li, Y., Xu, C., Ergun, M. A., … Mandelblatt, J. S. (2018). Association of Screening and Treatment With Breast Cancer Mortality by Molecular Subtype in US Women, 2000-2012. JAMA, 319(2), 154–164. https://doi.org/10.1001/jama.2017.19130 DOI: https://doi.org/10.1001/jama.2017.19130
Reeve, B. B., Stover, A. M., Alfano, C. M., Smith, A. W., Ballard-Barbash, R., Bernstein, L., McTiernan, A., Baumgartner, K. B., & Piper, B. F. (2012). The Piper Fatigue Scale-12 (PFS-12): psychometric findings and item reduction in a cohort of breast cancer survivors. Breast Cancer Research and Treatment, 136(1), 9–20. https://doi.org/10.1007/s10549-012-2212-4 DOI: https://doi.org/10.1007/s10549-012-2212-4
Reinertsen, K. V., Cvancarova, M., Loge, J. H., Edvardsen, H., Wist, E., & Fosså, S. D. (2010). Predictors and course of chronic fatigue in long-term breast cancer survivors. Journal of Cancer Survivorship: Research and Practice, 4(4), 405–414. https://doi.org/10.1007/s11764-010-0145-7 DOI: https://doi.org/10.1007/s11764-010-0145-7
Roberts, K. E., Rickett, K., Feng, S., Vagenas, D., & Woodward, N. E. (2020). Exercise therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer. The Cochrane Database of Systematic Reviews, 1(1), CD012988. https://doi.org/10.1002/14651858.CD012988.pub2 DOI: https://doi.org/10.1002/14651858.CD012988.pub2
Ruiz-Casado, A., Alejo, L. B., Santos-Lozano, A., Soria, A., Ortega, M. J., Pagola, I., Fiuza-Luces, C., Palomo, I., Garatachea, N., Cebolla, H., & Lucia, A. (2016). Validity of the Physical Activity Questionnaires IPAQ-SF and GPAQ for Cancer Survivors: Insights from a Spanish Cohort. International Journal of Sports Medicine, 37(12), 979–985. https://doi.org/10.1055/s-0042-103967 DOI: https://doi.org/10.1055/s-0042-103967
Ruiz-Casado, A., Álvarez-Bustos, A., de Pedro, C. G., Méndez-Otero, M., & Romero-Elías, M. (2021). Cancer-related Fatigue in Breast Cancer Survivors: A Review. Clinical Breast Cancer, 21(1), 10–25. https://doi.org/10.1016/j.clbc.2020.07.011 DOI: https://doi.org/10.1016/j.clbc.2020.07.011
Servaes, P., Gielissen, M. F., Verhagen, S., & Bleijenberg, G. (2007). The course of severe fatigue in disease-free breast cancer patients: a longitudinal study. Psycho-oncology, 16(9), 787–795. https://doi.org/10.1002/pon.1120 DOI: https://doi.org/10.1002/pon.1120
Soldato, D., Arecco, L., Agostinetto, E., Franzoi, M. A., Mariamidze, E., Begijanashvili, S., Brunetti, N., Spinaci, S., Solinas, C., Vaz-Luis, I., Di Meglio, A., & Lambertini, M. (2023). The Future of Breast Cancer Research in the Survivorship Field. Oncology and therapy, 11(2), 199–229. https://doi.org/10.1007/s40487-023-00225-8 DOI: https://doi.org/10.1007/s40487-023-00225-8
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660 DOI: https://doi.org/10.3322/caac.21660
Waks, A. G., & Winer, E. P. (2019). Breast Cancer Treatment: A Review. JAMA, 321(3), 288–300. https://doi.org/10.1001/jama.2018.19323 DOI: https://doi.org/10.1001/jama.2018.19323
Yang, S., Chu, S., Gao, Y., Ai, Q., Liu, Y., Li, X., & Chen, N. (2019). A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis. Cells, 8(7), 738. https://doi.org/10.3390/cells8070738 DOI: https://doi.org/10.3390/cells8070738
Yost, K. J., Yount, S. E., Eton, D. T., Silberman, C., Broughton-Heyes, A., & Cella, D. (2005). Validation of the Functional Assessment of Cancer Therapy-Breast Symptom Index (FBSI). Breast Cancer Research and Treatment, 90(3), 295–298. https://doi.org/10.1007/s10549-004-5024-3 DOI: https://doi.org/10.1007/s10549-004-5024-3
Zhao, F., Ren, D., Shen, G., Ahmad, R., Dong, L., Du, F., & Zhao, J. (2020). Toxicity of extended adjuvant endocrine with aromatase inhibitors in patients with postmenopausal breast cancer: A Systemtic review and Meta-analysis. Critical Reviews in Oncology/Hematology, 156, 103114. https://doi.org/10.1016/j.critrevonc.2020.103114 DOI: https://doi.org/10.1016/j.critrevonc.2020.103114